In Vivo Toxicological and Microbiological Activity of Marrubium vulgare L.on Candida albicans Isolated from Nosocomial Infections
نویسندگان
چکیده
منابع مشابه
In vivo and in vitro Pathogenesis and Virulence Factors of Candida albicans Strains Isolated from Cutaneous Candidiasis
Background: The Candida albicans is one of the most important global opportunistic pathogens, and the incidence of candidiasis has increased over the past few decades. Despite the established role of skin in defense against fungal invasion, little has been documented about the pathogenesis of Candida species when changing from normal flora to pathogens of vaginal and gastrointestinal epithelia....
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Crude extracts of the aerial parts of Marrubium vulgare show a potent in vitro inhibition of KCl-induced contraction of rat aorta. Bio-guided fractionations, spectroscopic analysis and chemical derivatization revealed the furanic labdane diterpenes marrubenol and marrubiin as the most active compounds.
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The progress in medicine over the last two decades with introduction of new technologies and therapies, which has allowed the survival of more and more patients suffering from serious diseases, has brought about an increase in the number of hospitalised and immunocompromised subjects. These individuals are highly susceptible to nosocomial fungal infections, especially to candidosis. Candida spp...
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Background and Purpose: Candida species are the most common organisms involved in superficial fungal infections, worldwide. Although econazole is among the most frequently used topical formulations for the treatment of candidiasis, no information is available regarding the susceptibility profiles of Candida species in Iran. Materials and Methods: In vitro susceptibility of 100 clinical Candida...
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Being normally a frequent commensal organism of the oro-gastrointestinal tract as well as the vulvovaginal cavity in immunocompetent individuals, Candida albicans also represents a major cause of opportunistic infections in locally or systemically immunocompromised hosts. Subsequent symptoms vary and range from superficial thrush to life-threatening systemic infections. The complement system is...
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ژورنال
عنوان ژورنال: Pharmaceutical Sciences
سال: 2020
ISSN: 1735-403X,2383-2886
DOI: 10.34172/ps.2020.35